Possible Effects of Long-Term Use

Superinfections, especially from yeast organisms. Severe colitis with persistent diarrhea.

Suggested Periodic Examinations While Taking This Drug (at physician's

discretion) Complete blood cell counts, liver function tests.

While Taking This Drug, Observe the Following

Foods: No restrictions.

Alcohol: No interactions expected.

Tobacco Smoking: No interactions expected. Other Drugs

Clindamycin taken concurrently with

• antidiarrheal drugs (diphenoxylate, loperamide, paregoric) may result
in worsening of the underlying colitis because of impaired elimination
of causative toxins.

• antimyasthenic drugs (ambenonium, neostigmine, pyridostigmine)
may reduce their effectiveness in relieving the muscle weakness of
myasthenia gravis.

The following drugs may decrease the effects of clindamycin

• chloramphenicol (Chloromycetin).

• erythromycin (E.E.S., E-Mycin, etc.).

Driving, Hazardous Activities: This drug may cause nausea and diarrhea. Restrict activities as necessary.

Aviation Note: The use of this drug may be a disqualification for piloting. Consult a designated Aviation Medical Examiner.

Exposure to Sun: Use caution until sensitivity is determined.

Discontinuation: If tolerated satisfactorily, take the full course prescribed. When used to treat infections that may predispose to rheumatic fever or nephritis, take continually in full dosage for no less than 10 days.

Special Storage Instructions: Oral solution should be kept at room temperature; do not refrigerate.

Observe the Following Expiration Times: Do not take the oral solution if it.

TEXT 9. Read the following text and make up a dialogue using information from the text.

IBUPROFEN

(i BYU proh fen)

Introduced: 1969

Class: Mild analgesic, anti-inflammatory

Prescription: USA: Varies

Controlled Drug: USA: No Canada: Yes

Available as Generic: Yes

Brand Names: Advil, Apo-Ibuprofen, Children's Advil, CoAdvil [CD], Nuprin, PediaProfen,

Principal Uses

As a Single Drug Product: Used primarily to relieve mild to moderately severe pain associated with (1) musculoskeletal injuries; (2) acute and chronic gout, rheumatoid arthritis and osteoarthritis; (3) dental, obstet­rical and orthopedic surgery; (4) menstrual cramps; (5) vascular (mi-grainelike) headaches; and (6) to reduce fever.

How This Drug Works: Not completely established. It is thought that this drug reduces the tissue concentrations of prostaglandins (and related compounds), chemicals involved in the production of inflammation and pain.