Ratio of mass to the volume of the freely poured material

*Ratio of tablet mass to its diameter

*Ratio of bulk mass to a true density

! Specify, what device determine factional composition of powders and granules:

*Device of KHNIKHFI

*Microscope with a micrometrical line

*Device of VP-12À

*+Standard set of sieves

*Device 545-P-À K-3

! On a pharmaceutical factory produce the tablets of sodium chloride. Specify the method of their preparation.

*Pressing with previous wet granulation

*Forming

*Direct pressing with addition of auxiliary substances

*+Direct pressing, without auxiliary substances

*Pressing with previous dry granulation

! Name a conditions, necessary for the receipt of pills by the method of the direct pressing

*If bulk mass exceeds the specific density of powders

*Pressed the masses should be a multicomponent

*Presence of machines of the double pressing

*On condition of presence of vacuum in matrices

*+The pressed substances should have isodiametrical crystals

! Name the details of " press-instrument" in tablet machine:

*Load funnel, matrix

*+Lower and overhead punches, matrix

*Agitators, overhead puncheon

*Feeder-metering device, overhead and lower punches

*Matrix, agitators

! In the process of pressing the tablets adhere to the pressing tool. The technological error is the lack of:

*Diluents

*Adhesive substances

*Disintegrants

*+Lubricants

*Dyes

! For drying of granules utillize the different types of dryers. Specify, to what type concern dryer SP-30:

*+with a fluidized bed layer

*Sublimation

*Infra-red dryer

*with a silica gel column

*with the forced circulation of air

! A tablet production unit produces press-coated tablets. What equipment is used for this purpose?

*Triturating machine

*Dragee pan

*Marmerizer

*Eccentric tabletting machine

*+Double pressing tabletting machine

! The tablet department of a factory produces film coated tablets. Specify the types of film coats:

*Insoluble, soluble in a stomach

*Dragee, insoluble

*Dry, watersoluble

*+Watersoluble; soluble in a stomach, intestinal soluble, insoluble

*Insoluble, soluble in an intestine

! The tablet department of a factory produces tablets with suspension coats. Choose a compose of suspensions which can be utillized for the coating of tablets-corns:

*+Granulated sugar, water, polyvinylpirrolidon, aerosil, basic magnesium carbonate, titanium dioxide, dye

*Granulated sugar, solution of methylcellulose, titanium dioxide, polyvinylpirrolidon

*Granulated sugar, dye, magnesium carbonate, magnesium oxide, sodium carboxymethylcellulose

*Granulated sugar, alcohol mixture, sodium carboxymethylcellulose, magnesium oxide, aerosil, dye

*Sodium carboxymethylcellulose, granulated sugar, water, glycerin, magnesium oxide, aerosil, titanium dioxide

! Quality control department on a pharmaceutical enterprises conduct the test of determination of strength on abrade of pills. Specify, what device is utillized for this determination:

*+Drum friabilator

*Goniometer

*Spring dynamometer

*Laboratory indicator of process of disintegration

*Laboratory indicator of process of dissolution

! Quality of pills is estimated by different indexes. Specify a device which is applied for determination of tablets disintegration.

*Flowing device

*+Swinging basket

*Device of KHNIKHFI

*Device with a blade

*Friabilator

! Tablet workshop produces coated tablets, soluble in an intestine. Specify disintegrating time of this pills:

*No more than 15 min

*Must not disintegrate during 30 min in 0, 1 M solution of HCl, and after washing by water must disintegrate during 30 minsin 0, 1 M solution of NaOH

*+Must not disintegrate during 1 hour in 0, 1 M solution of HCl and after washing by water - to disintegrate during 1 hour in 0, 1M solution of NaOH

*No more than 30 min

*No more than 45 min

! At quality control of pills found rejection in the indexes of pills appearance (a surface does not answer requirements of USP). What technological methods should be used in further production to eliminate this rejections?

*High-speed of rotor

*+Precondition and state of punches

*In-bulk little auxiliary matters

*Factional compose does not correspond a norm

*Bad fluidity of mass

! At quality control of gelatinous capsules determine solubility. Choose the correct time mode for the determination of this parameter.

*+If for 45 minutes a not less than 75% of active substance dissolved in water.

*If for 60 minutes 75% of active substance dissolved in water.

*If for 30 minutes not less than 55 % of active substance dissolved in water.

*If for 90 minutes not less than 85 % of active substance dissolved in water.

*If for 45 minutes not less than 70 % of active substance dissolved in water.

! At the production of gelatinous capsules the overheat of gelatinous mass over 85°С took a place. What negative phenomenon did it result in?

* To brightening of solution

* Denaturizing of gelatin

* To discoloration solution

* To appearance of extraneous smell

*+To the increase of viscidity of solution and denaturizing of gelatin

! To the physical and chemical methods of microcapsules obtaining concern:

* Dragee method

*+Method of coacervation

* Method of dispersion

* Spraying in the fluidized bed layer

* Method of liquid dispergating

! What legal document approved for a limited time establishes the technical requirements for the

quality of the drug or medicinal plants?

*+ Temporary Pharmacopoeia article (TFS)

* Technology Industry Regulations (TPR)

* Pharmacopoeia article (FC)

* State Standard (DSTU)

* Industry Standard (GATS)

! Define tubatiny dosage form:

* egg-shaped capsules, obtained by pressing.

* spherical capsules, obtained by immersion.

*+ soft capsules with extended neck.

*Hard capsules with a lid, which are filled with micro-capsules.

* Soft rectal capsules in the form of an elongated drop.

! What technology has the pharmacist to offer in the industrial manufacture of tablets of sodium

chloride:

* dry granulation.

* granulation with a spray drying;

* Wet granulation;

* Doing pills

*+ Direct moving;

! Other ingredients in the manufacture of tablets are needed to provide a tablet weight with the

necessary technological properties, to ensure the accuracy of dosing, mechanical strength and stability of the tablets during storage. Which excipients improve the disintegration or dissolution of tablets in the body?

* Filler;

* Anti-friction material;

* slippery substances;

*+ disintegrating agents;

*Coregents.

! The pharmaceutical company produces powders. Specify how to introduce essential oils into the complex powders.

*+ Mix with a small amount of powder and load last into a mixer or prepare alcoholic solutions and spray them onto the powder mixture.

* Mix a small amount of powder and load last into a mixer.

* Prepare alcoholic solution and sprayed onto the powder mixture.

* Mix with a small amount of powder and load into a mixer in the first place, or prepare alcoholic solutions and spray onto the powder mixture

* Prepare hydrogen solutions and spray onto the mixture of powders

! To evaluate the appearance of the tablets its size is determined. Specify which device is used for this study:

* micrometer

*+ calipers

* compass

* millimeter ruler

* centimeter ruler

! Pharmaceutical enterprise is developing a new product release. Which part of technological rules describes the appearance, physical and chemical properties of finished product?

*Description of technological process

*+Characteristic of the final product

*Characteristic of raw materials and intermediate products

*Characteristic of auxiliary products

*Information data

! Rules of GMP WHO classify clean rooms into classes:

*+А, В, С, D

*А and В

*І, ІІ and ІІІ

*І and ІІ

*А, Б, В, Г, Д

! A pharmaceutical factory produces camphor oil for topical application. What oil is to be used as a solvent?

* Plum

*Peach

*Vaseline

*Olive

*+Sunflower seed

! A department of a pharmaceutical plant produces injection solutions. Ascorbic acid solution for injections relates to the following group of solutions:

* Solutions of salts derived from weak bases and strong acids

* Solutions of substances that should be subjected to thermal sterilization

* +Easily oxidized solutions

* Solutions of salts derived from strong bases and weak acids

* Solutions of substances requiring special rectification