Table 23

Testosterone: Improvement in Sexual Intercourse Outcomes.

Table 24

Testosterone (T) Combined with PDE-5 inhibitors: Improvement in Sexual Intercourse Outcomes.

Table 25

Testosterone Treatment: Improvement in Erections.

Table 26

Testosterone Treatment: Patients with Adverse Events.

Interventions

Of the 21 trials involving testosterone therapy for treatment of male ED, most assessed testosterone monotherapy including oral, ^{145, 316, 319, 324} intramuscular (IM), ^{325, 326, 328} gel, ^{231, 317, 320, 327} patch, ^{317, 320, 327, 330} and cream forms.^{322, 329} Five trials studied testosterone in combination with a phosphodiesterase inhibitor.^{5, 77, 145, 231} Two other trials studied a cream combining testosterone, isosorbide dinitrate and co-dergocrine.^{322, 329} Finally, one trial compared dihydrotestosterone gel versus placebo.³²¹