Aortic stenosis as a systemic disease

Several lines of evidence suggest that aortic stenosis is not simply a mechanical problem limited to the valve leaflets. The disease affects the upstream left ventricle and the downstream systemic vasculature, as well as the valve itself (FIGURE 3 Anatomical Changes Associated with Aortic Stenosis.). Anatomically, abnormal tissue calcification affects the entire cardiovascular system, not just the aortic valve. In addition, dilatation of the ascending aorta is common and may need to be addressed at the time of valve replacement. The association between aortic stenosis and aortic dilatation is complicated by the phenotypic overlap between calcific aortic stenosis and congenital bicuspid-valve disease. Patients with bicuspid aortic valves, as compared with those with trileaflet aortic valves, have larger aortic diameters and an increased long-term risk of aortic dissection, with estimates of 3.1 cases per 10, 000 patient-years, for an age-adjusted relative risk of 8.4.

In some patients with aortic stenosis, angiodysplastic gastrointestinal bleeding is seen in association with an acquired deficiency of von Willebrand factor multimers, a condition known as Heyde's syndrome. Unfolding of the von Willebrand multimers owing to abnormal shear stress as blood passes through the narrow valve results in cleavage by a specific plasma metalloproteinase. Low levels of von Willebrand factor also affect platelet function and may confer a predisposition to angiogenesis; these abnormalities typically normalize after valve replacement. Clinically, there is a complex interplay between increased bleeding and thrombotic events, with some studies showing enhanced thrombin formation and platelet activation. Rheumatic aortic stenosis is usually accompanied by mitral-valve disease and is more likely than calcific disease to manifest as mixed stenosis and regurgitation of both valves, rather than as an isolated single-valve lesion, a factor that can complicate decision making. In addition, rheumatic-valve disease is often associated with tricuspid-valve involvement, pulmonary hypertension, and right-heart dysfunction.

Adverse cardiovascular outcomes are seen with aortic-valve calcification even in the absence of valve obstruction. In the Cardiovascular Health Study (CHS), the presence of aortic sclerosis in adults older than 65 years of age without known coronary artery disease was associated with a 52% increase in the risk of death from cardiovascular causes and a 40% increase in the risk of myocardial infarction over the course of 5 years, even when the analysis was corrected for known cardiovascular risk factors. In the higher-risk population in the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) study, aortic-valve sclerosis in patients without known cardiovascular disease was associated with a doubling of cardiovascular risk. In a population similar to the CHS cohort, the Multi-Ethnic Study of Atherosclerosis (MESA) showed that aortic-valve calcification was associated with a 50% increase in the risk of cardiovascular events. Similarly, in the Heinz Nixdorf Recall Study, the degree of aortic-valve calcification provided additive value to Framingham Heart Study risk factors for the prediction of cardiovascular events. Further studies are needed to explore whether aortic sclerosis is a marker of coronary artery disease or whether it reflects a shared underlying risk factor, such as systemic inflammation.